Defense of Laurine Nieuwjaer Ziane thesis - September 26, 2023
Laurine Ziane defended her PhD thesis entitled « Develepment of a light emitting device for the treatment of ovarian peritoneal carcinomatosis by intracavitary photodynamic therapy »
Publication of French standard NF G20-030: Luminous textiles - Determination of the irradiance and luminance of luminous fabrics
French standard NF G20-030: Luminous textiles - Determination of the irradiance and luminance of luminous fabrics has just been published. OncoThAI, in particular, Elise THECUA, participated in [...]
A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid
The article entitled "A facile fabrication of dissolving microneedles containing 5-aminolevulinic acid" By Mathilde CHAMPEAU and al is now online. This project is performed thanks to a collaboration [...]
OncoThAI represented by
Pr. Nadira Delhem
Bâtiment OncoLille
Frédéric Combemale
59000 Lille
Phone: +33 320 446 709
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Press release
Innovative laser technology to treat glioblastomas: Download the press release21.58 MB (October 2017)
Images to download
Download the images archive86.12 MB
INDYGO clinical trial overview
Download the press review 13.81 MB [French only] (September - October 2017)
Download the Nature Outlook 1.02 MB (September 27, 2018)
The project ONCO-THAI aims to develop minimally invasive therapies based on light and medical imaging
This project leads to the development of technical platforms (hardware and software). These platforms integrate results obtained on mathematical modeling of light-tissue interaction (LITT: Laser Interstitial Thermo-Therapy and PDT: Photodynamic Therapy) and on medical imaging for the identification of cancer foci using Mutimodality Imaging iii) simulation, planning and monitoring of treatment procedures.
Main research programs concern
The project is divided in two sub-themes: Focal interstitial laser therapy for prostate cancer, brain (glioblastoma) and Intracavity laser therapy for peritoneal carcinoses or mesothelioma.
Light Efficiency Calculator
Photodynamic therapy is a well-established treatment for various dermatological diseases including actinic keratoses (AK).
Although the clinically approved protocols for PDT of AK require irradiation with red light or daylight in Europe and with blue light in USA, there is a growing interest in other lights particularly in white lights.
Light sources can be characterized by various quantities : illuminance (lux), irradiance (W/cm²), effective irradiance (W/cm²).
To compare the consistency of the light sources, it may be necessary to switch from one quantity to another. We have therefore developed a computer software "Light Efficiency Calculator for PpIX PDT" that, from any spectral irradiance automatically and instantly displays the values of the illuminance, the irradiance and the effective irradiance.
This software has been filed with the computing program protection agency and is avalaible online : http://www.oncothai.fr/light-efficiency-calculator/index.php
Dicom viewer RT
The “radiotherapy structure set” (RTSTRUCT) object of the DICOM standard is used for the transfer of patient structures and related data. It contains mainly the information for regions of interest (ROIs) and points of interest.
For futher informations, please refer to the DICOM NEMA standard here.
The Inserm U1189 OncoThAI unit developed tools for viewing dicom images and RT-STRUCT dicom images.
Brochures
DermatoPDT
MesoPDT
NeuroPDT
Prodynov
ImmunoPDT
Newsletter
Download newsletter October 2018 [French]
Download newsletter December 2018 [French]
OncoThAI "Laser Assisted Therapies and Immunotherapies for Oncology" is directed by Pr. Nadira DELHEM.
This laboratory (INSERM, University of Lille, CHU) is composed of 2 teams:
- ImmunoPDT and Immunotherapy for Cancer directed by Pr. Nadira DELHEM
- PhysicoPDT directed by Dr. Anne-Sophie VIGNION-DEWALLE
OncoThAI develops an innovative therapy, Photodynamic Therapy (PDT), essentially for cancers that have reached a therapeutic impasse.
Indeed, the use of PDT in oncology has been of growing interest for several years.
This property would be a major asset in oncology considering the revolutionary success of anti-tumor immunotherapies over the last 3 years. Based on this rationale, the activities of the ImmunoPDT team aim to develop fundamental and translational clinical projects to characterize the effects of PDT, used alone or in combination with conventional therapies, on the regulation of the immune response.
PhysicoPDT develops the technologies required for the implementation of PDT in human clinics. In addition to mathematical modelling of mechanisms (in-silico studies), the team has recognized expertise in treatment planning, simulation, light dosimetry and medical device design.
Finally, the team relies on proven expertise in the implementation of clinical protocols to evaluate PDT, in particular thanks to a very strong involvement of clinicians within OncoThAI.
